𝗘𝘃𝗲𝗿𝘆 𝘆𝗲𝗮𝗿 𝗼𝗻 𝗝𝘂𝗹𝘆 𝟮𝟴, 𝗪𝗼𝗿𝗹𝗱 𝗛𝗲𝗽𝗮𝘁𝗶𝘁𝗶𝘀 𝗗𝗮𝘆 𝗶𝘀 𝗺𝗮𝗿𝗸𝗲𝗱 𝘁𝗼 𝗿𝗮𝗶𝘀𝗲 𝗮𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗼𝗳 𝘃𝗶𝗿𝗮𝗹 𝗵𝗲𝗽𝗮𝘁𝗶𝘁𝗶𝘀, 𝗮𝗻 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝗹𝗶𝘃𝗲𝗿 𝘁𝗵𝗮𝘁 𝗰𝗮𝘂𝘀𝗲𝘀 𝘀𝗲𝗿𝗶𝗼𝘂𝘀 𝗹𝗶𝘃𝗲𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝗮𝗻𝗱 𝗵𝗲𝗽𝗮𝘁𝗼𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗰𝗮𝗻𝗰𝗲𝗿. 𝗧𝗵𝗶𝘀 𝘆𝗲𝗮𝗿’𝘀 𝘁𝗵𝗲𝗺𝗲 𝗶𝘀 “𝗛𝗲𝗽𝗮𝘁𝗶𝘁𝗶𝘀 𝗖𝗮𝗻’𝘁 𝗪𝗮𝗶𝘁,” #𝗛𝗲𝗽𝗖𝗮𝗻𝘁𝗪𝗮𝗶𝘁 𝗲𝗺𝗽𝗵𝗮𝘀𝗶𝘇𝗶𝗻𝗴 𝘁𝗵𝗲 𝘂𝗿𝗴𝗲𝗻𝗰𝘆 𝗼𝗳 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝘀 𝗿𝗲𝗾𝘂𝗶𝗿𝗲𝗱 𝘁𝗼 𝗲𝗿𝗮𝗱𝗶𝗰𝗮𝘁𝗲 𝗵𝗲𝗽𝗮𝘁𝗶𝘁𝗶𝘀 𝗮𝘀 𝗮 𝗽𝘂𝗯𝗹𝗶𝗰 𝗵𝗲𝗮𝗹𝘁𝗵 𝘁𝗵𝗿𝗲𝗮𝘁 𝗯𝘆 𝟮𝟬𝟯𝟬.
Hepatitis E, less spoken about than the B and C variants, is a liver infection caused by the hepatitis E virus (HEV). It is shed in the stools of infected persons and enters the human body through the intestine, most commonly by drinking HEV-contaminated drinking water.
There are four main types of HEV; referred to as genotypes 1, 2, 3, and 4, with genotypes 1 and 2 only being found in humans and genotypes 3 and 4 being found primarily in animals but, on occasions, in humans. HEV resulting from the consumption of contaminated water causes mostly a genotype 1 infection and much less frequently a genotype 2 infection. Hepatitis E infection is unusual in regions with improved sanitation and water supply, the majority of these cases are caused by genotype 3 virus and are caused by infection with virus originating in animals, generally through the consumption of raw meat, particularly pork.
CoCID is an EU-funded project, initiated by SiriusXT, whose major objective is to demonstrate the benefits of using soft x-ray microscopy as a research tool to assist virologists in understanding the intracellular phases of viral reproduction as well as to develop treatments to inhibit virus spread. Hepatitis-E is one of the virus use cases being addressed by project CoCID, with this research being led by Dr. Nicola Fletcher, Assistant Professor of Veterinary Bioscience at University College Dublin.
A key focus of Dr. Fletcher’s research is to develop model systems that mimic the features of livers in the laboratory. Her team is currently developing liver organoids, which are 3D spherical ‘mini livers’, to better understand how HEV infects both pig and human liver cells.
”CoCID employs soft x-ray microscopy to bridge the current gap between light and electron microscopy and will serve as an interface for correlative studies”, said Dr. Fletcher.